Novel Nanoformulations to Overcome Obstacles in Herbal Drug Delivery for Alzheimer's Disease

Deepak Kumar; Pranay Wal; Ankita Wal; Mohd Qasid Lari; Astik Manju Ashesh; Dileep Kumar; Sandeep Kumar Singh; Bhupendra Kumar Singh; Ajay Kumar

doi:10.2174/0115680266362594250527112018

Novel Nanoformulations to Overcome Obstacles in Herbal Drug Delivery for Alzheimer's Disease

Curr Top Med Chem. 2025 Jun 27. doi: 10.2174/0115680266362594250527112018. Online ahead of print.

Authors

Deepak Kumar¹, Pranay Wal², Ankita Wal², Mohd Qasid Lari¹, Astik Manju Ashesh¹, Dileep Kumar³, Sandeep Kumar Singh⁴, Bhupendra Kumar Singh⁵, Ajay Kumar¹

Affiliations

¹ Sardar Patel College of Pharmacy, Medical College Road, Gorakhpur 273013, (U.P.), India.
² Pranveer Singh Institute of Technology, Kanpur, 209305, (U.P.), India.
³ Poona College of Pharmacy, Bharati Vidyapeeth University, Bharati Vidyapeeth Educational Complex, More Vidyalaya Campus, Eradwane, Paun Road, Pune - 411038.
⁴ Department of Pharmaceutical Science and Technology, Madan Mohan Malviya University of Technology, Gorakhpur, (U.P.), India.
⁵ School of Pharmacy, Graphic Era Hill University, Dehradun-248002, India & Department of Pharmacy, S. N. Medical College, Agra-282002, India.

PMID: 40589006
DOI: 10.2174/0115680266362594250527112018

Abstract

Introduction: Nanomedicine is a rapidly growing field in pharmaceutical science, driven by the enhanced quality of nano-formulations that improve the treatment of various diseases. Nano-sized novel drug delivery techniques for herbal pharmaceuticals have the potential to enhance activity and address concerns related to medicinal plants in the future. Natural chemicals show promise in various neurodegenerative diseases, but their permeability across the blood-brain barrier prevents them from reaching the nervous system. By improving molecular monitoring, synthesis, and diagnostics, pharmaceutical nanotechnology provides improved controlled drug delivery for the treatment of neurodegeneration.

Method: The evaluated and investigated data from recent studies were gathered using Google Scholar as a search engine. We reviewed and analysed research publications from databases like Bentham Science, Elsevier, PubMed, and ScienceDirect, among others, to summarize the findings.

Results: Curcumin, Centella asiatica, thymoquinone, Hypericum perforatum, Panax ginseng, quercetin, piperine, and a variety of other herbs and herbal medicines have all been examined for their potential to aid in the treatment of brain disorders like Alzheimer's disease. To enhance drug bioavailability in the brain, nanoformulations, including phytosomes, transferosomes, ethosomes, and niosomes, have been utilized as pharmaceuticals.

Conclusion: Herbs and herbal medicines have been synthesized into nanoparticle form to enhance tissue distribution, achieve sustained delivery, and protect against physicochemical degradation while also increasing the solubility and bioavailability of poorly soluble herbal products. To overcome physiological complications, researchers must develop lab-scale approaches, characterization methodologies, and targeting tactics for nanoformulations with high translational potential early in product development.

Keywords: Alzheimer’s disease; Nanoformulations; ethosomes; herbal nanoformulations; liposomes; niosomes; phytopharmaceuticals; transfersomes..