Identification of the Novel HLA-C*15:271N Allele by Next Generation Sequencing

HLA. 2025 Jul;106(1):e70299. doi: 10.1111/tan.70299.

Abstract

HLA-C*15:271N differs from HLA-C*15:02:01:01 by an insertion in exon 3 leading to a premature termination codon.

Keywords: C*15:271N; HLA‐C; NGS; organ transplantation.

MeSH terms

  • Alleles
  • Base Sequence
  • Codon, Nonsense*
  • Exons*
  • HLA-C Antigens* / genetics
  • High-Throughput Nucleotide Sequencing
  • Histocompatibility Testing
  • Humans
  • Sequence Analysis, DNA

Substances

  • Codon, Nonsense
  • HLA-C Antigens