Infected pericardial effusion caused by Prevotella intermedia: a rare diagnosis

Front Cell Infect Microbiol. 2025 Jun 16:15:1612282. doi: 10.3389/fcimb.2025.1612282. eCollection 2025.

Abstract

Prevotella intermedia is a Gram-negative bacterium that thrives in anaerobic environments. It presents challenges in detection through routine laboratory assays, and hitherto, there has been no documented instance of detecting this bacterium in pericardial effusion in China. Metagenomic Next-Generation Sequencing (mNGS) can boost the detection rate of this pathogen and furnish early guidance for clinical management.

Keywords: Prevotella intermedia; infection; mNGs; pericardial effusion; pericardial tamponade.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bacteroidaceae Infections* / diagnosis
  • Bacteroidaceae Infections* / microbiology
  • China
  • Female
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Metagenomics
  • Pericardial Effusion* / diagnosis
  • Pericardial Effusion* / microbiology
  • Prevotella intermedia* / genetics
  • Prevotella intermedia* / isolation & purification
  • RNA, Ribosomal, 16S / genetics

Substances

  • Anti-Bacterial Agents
  • RNA, Ribosomal, 16S