Ni-Catalyzed intramolecular cyclization of Baylis-Hillman adducts of 2-cyanoaniline towards 2,3-dihydroquinolin-4(1 H)-ones

Org Biomol Chem. 2025 Jul 2. doi: 10.1039/d5ob00778j. Online ahead of print.

Abstract

A Ni-catalyzed reductive cyclization of Baylis-Hillman adducts of 2-cyanoaniline is presented. A novel class of quinolin-4-ones containing a quaternary carbon center were synthesized in moderate to good yields. With iPr-PyBOX as a chiral ligand, the catalytic enantioselective cyclization gave a moderate yield and ee.