Systematic Review of Natural Briaranes in Marine Organisms (2020-2024): Chemical Structures and Bioactivities

Li-Guo Zheng; Yu-Chia Chang; Yu-Chi Tsai; Yi-Hao Lo; Wei-Chiung Chi; Mingzi M Zhang; Lun Kelvin Tsou; Zhi-Hong Wen; Tsong-Long Hwang; You-Ying Chen; Ping-Jyun Sung

doi:10.1248/cpb.c25-00255

Systematic Review of Natural Briaranes in Marine Organisms (2020-2024): Chemical Structures and Bioactivities

Chem Pharm Bull (Tokyo). 2025;73(7):581-594. doi: 10.1248/cpb.c25-00255.

Authors

Li-Guo Zheng^{1

2}, Yu-Chia Chang^{3

4}, Yu-Chi Tsai⁵, Yi-Hao Lo^{6

7

8}, Wei-Chiung Chi⁹, Mingzi M Zhang¹⁰, Lun Kelvin Tsou¹¹, Zhi-Hong Wen^{2

12}, Tsong-Long Hwang^{3

13

14

15}, You-Ying Chen^{2

16

17}, Ping-Jyun Sung^{2

12

18

19

20

21}

Affiliations

¹ Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University.
² National Museum of Marine Biology & Aquarium.
³ Center for Drug Research and Development and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology.
⁴ Department of Cosmetic Science, Chang Gung University of Science and Technology.
⁵ School of Chinese Medicine, College of Chinese Medicine, China Medical University.
⁶ Department of Family Medicine, Zuoying Armed Forces General Hospital.
⁷ Institute of Medical Science and Technology, National Sun Yat-sen University.
⁸ Department of Nursing, Meiho University.
⁹ Department of Food Science, National Quemoy University.
¹⁰ Institute of Molecular and Genomic Medicine, National Health Research Institutes.
¹¹ Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes.
¹² Department of Marine Biotechnology and Resources, National Sun Yat-sen University.
¹³ Department of Anesthesiology, Chang Gung Memorial Hospital.
¹⁴ Department of Chemical Engineering, Ming Chi University of Technology.
¹⁵ Graduate Institute of Natural Products, College of Medicine, Chang Gung University.
¹⁶ Xiamen Key Laboratory of Natural Products Resources of Marine Medicine, Xiamen Medical College.
¹⁷ Fujian Provincial University Marine Biomedical Resources Engineering Research Center, Xiamen Medical College.
¹⁸ Chinese Medicine Research and Development Center, China Medical University Hospital.
¹⁹ Graduate Institute of Natural Products, Kaohsiung Medical University.
²⁰ Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University.
²¹ Department of Biochemical and Molecular Medical Sciences (Currently known as Department of Biochemistry and Molecular Medicine), National Dong Hwa University.

PMID: 40603109
DOI: 10.1248/cpb.c25-00255

Abstract

This review summarizes the structures, names, and bioactivities of 207 briarane-type diterpenoids, including 113 newly identified metabolites, isolated between 2020 and 2024. All the briaranes discussed were derived from octocorals belonging to the genera Briareum, Dichotella, Ellisella, Junceella, and Erythropodium. Some of these compounds have demonstrated potential biomedical activities.

Keywords: Briareum; Dichotella; Ellisella; Erythropodium; Junceella; briarane.

Publication types

Systematic Review

MeSH terms

Animals
Aquatic Organisms* / chemistry
Aquatic Organisms* / metabolism
Biological Products* / chemistry
Biological Products* / isolation & purification
Biological Products* / pharmacology
Diterpenes* / chemistry
Diterpenes* / isolation & purification
Diterpenes* / metabolism
Diterpenes* / pharmacology
Humans
Molecular Structure

Substances

Biological Products
Diterpenes
briarane 1