The role and therapeutic value of NUSAP1 in human cancers

J Transl Med. 2025 Jul 2;23(1):725. doi: 10.1186/s12967-025-06746-2.

Abstract

In recent years, the incidence of cancer has increased, and early diagnosis and treatment are key to cancer treatment. Nucleolar and spindle-associated protein 1 (NUSAP1) is a crucial mitotic regulator. NUSAP1 binds to microtubules and mediates their attachment to chromosomes, ensuring the accurate distribution of genetic material to the two daughter cells. NUSAP1 is located on chromosome 15q15.1 and is typically expressed in proliferating cells, suggesting a potential oncogenic role. Studies have shown that NUSAP1 plays a significant role in various cancers, including breast cancer, cervical cancer, lung cancer, prostate cancer, and hepatocellular carcinoma. Furthermore, NUSAP1 may serve as a promising biomarker for cancer diagnosis and prognosis. In this review, we discuss the roles and mechanisms of NUSAP1 in human cancers.

Keywords: Biomarker; Cancer; Diagnosis; NUSAP1.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Humans
  • Microtubule-Associated Proteins* / metabolism
  • Neoplasms* / drug therapy
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Neoplasms* / therapy

Substances

  • Microtubule-Associated Proteins
  • NUSAP1 protein, human
  • Biomarkers, Tumor