The risk of hyperuricemia assessed by estimated glucose disposal rate

Abstract

Purpose: The estimated glucose disposal rate (eGDR) is a simple and noninvasive clinical measure used to assess insulin resistance (IR), yet its potential utility as a marker for hyperuricemia risk had not been systematically evaluated. This study aimed to investigate the relationship between eGDR and hyperuricemia risk among American adults.

Methods: Data for this cross-sectional study were obtained from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). Hyperuricemia was identified as a serum urate (SU) concentration of ≥7 mg/dL in males and ≥6 mg/dL in females. The relationship between eGDR and hyperuricemia risk was assessed using multivariate logistic regression and restricted cubic spline (RCS) methods, with additional subgroup and interaction analyses performed.

Results: With increasing eGDR values, the prevalence of hyperuricemia decreased significantly (29.93% vs. 19.11% vs. 13.20% vs. 5.03%, P <0.001). Multivariate logistic regression indicated that eGDR was independently associated with the risk of hyperuricemia after controlling for covariates including demographic, lifestyle, and clinical factors (OR=0.93, 95%CI: 0.90-0.96, P <0.001). RCS analysis further revealed a nonlinear relationship, with a turning point at eGDR 7.96 mg/kg/min. Subgroup analysis revealed a stronger inverse association between eGDR and hyperuricemia risk in females.

Conclusions: The eGDR is inversely associated with hyperuricemia and appears to be a promising epidemiological tool for evaluating the impact of IR on the risk of hyperuricemia.

Keywords: NHANES; estimated glucose disposal rate; hyperuricemia; insulin resistance; population-based study.