Six new resin derivatives from flowers of Humulus lupulus L. with anti-osteoporosis activities

Yabo Chen; Jiaojiao Chen; Kun Li; Yiping Jiang; Zhimin Dong; Tianshuang Xia; Hailiang Xin

doi:10.1080/14786419.2025.2526730

Six new resin derivatives from flowers of Humulus lupulus L. with anti-osteoporosis activities

Nat Prod Res. 2025 Jul 3:1-10. doi: 10.1080/14786419.2025.2526730. Online ahead of print.

Authors

Yabo Chen^{1

2}, Jiaojiao Chen³, Kun Li², Yiping Jiang², Zhimin Dong², Tianshuang Xia², Hailiang Xin^{1

2}

Affiliations

¹ School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fujian, P. R. China.
² School of Pharmacy, Naval Medical University, Shanghai, P. R. China.
³ The First Affiliated Hospital, Naval Medical University, Shanghai, P. R. China.

PMID: 40608985
DOI: 10.1080/14786419.2025.2526730

Abstract

Six new resin derivatives, humuluslupulus A-F (1-6), were isolated from flowers of Humulus lupulus L., together with thirteen known compounds (7-19). The structures of isolated compounds were identified by IR, HRESIMS, NMR analysis, and compared with data from the literature. The anti-osteoporosis activities of compounds 1-6 were evaluated by MTT assay and Western blot analysis in osteoblasts. Among them, compounds 2, 3, 4, 6 could increase the osteoblastic proliferation. Compounds 1-6 could all improve the expressions of bone formation related proteins, including Runx2, OPN and BMP-2. It can be confirmed that new resin derivatives of hop have potentialities for promoting osteoblastic bone formation.

Keywords: Humulus lupulus L; moraceae; osteoporosis activities; resin derivatives.