Targeting mechanotransduction in osteosarcoma

Ruoyun He; Peiqi Ding; Yanan She; Huixin Liang; Xianglin Mei; Qingyuan Gao; Lisha Li

doi:10.1016/j.bbrc.2025.152272

Targeting mechanotransduction in osteosarcoma

Biochem Biophys Res Commun. 2025 Jun 28:777:152272. doi: 10.1016/j.bbrc.2025.152272. Online ahead of print.

Authors

Ruoyun He¹, Peiqi Ding², Yanan She², Huixin Liang³, Xianglin Mei⁴, Qingyuan Gao², Lisha Li⁵

Affiliations

¹ The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, 130021, Jilin Province, China; The Second Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
² The Second Hospital of Jilin University, Changchun, 130021, Jilin Province, China.
³ China Japan Union Hospital of Jilin University, Changchun, 130033, Jilin Province, China.
⁴ Department of Pathology, The Second Hospital of Jilin University, Changchun, 130041, Jilin University, China.
⁵ The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, 130021, Jilin Province, China. Electronic address: lilisha@jlu.edu.cn.

PMID: 40609212
DOI: 10.1016/j.bbrc.2025.152272

Abstract

Osteosarcoma (OS) is a common primary bone malignancy predominantly affecting adolescents. The bone microenvironment is crucial in modulating the initiation and progression of OS. OS cells transduce mechanical signals into biochemical signals, thereby regulating cellular behavior. A comprehensive examination of the complexities of mechanotransduction in OS strengthens the theoretical framework for understanding its regulatory mechanisms. Existing theoretical frameworks often fail to integrate biomechanical cues with epigenetic regulation, which is essential for a comprehensive understanding of OS pathogenesis. This review highlights the aberrant mechanotransduction in OS cells, contrasting with physiological bone remodeling, examines key signaling molecules involved, and summarizes potential therapeutic strategies targeting mechanotransduction. These insights provide a foundation for developing innovative and targeted therapies for OS.

Keywords: Mechanotransduction; Osteosarcoma; Signaling pathway; Treatment strategy.

Publication types

Review