The pandemic of coronavirus disease 2019 (COVID-19) has impacted our lifestyles. On the one hand, the patients with hematological malignancies (HM) are more vulnerable to COVID-19 infection. Once infected with COVID-19, these patients tend to develop into severe type with a higher mortality rate. Although patients with HM demonstrated a reduced response to COVID-19 vaccines, they still can benefit from vaccine injection with reduced rates of viral infection and incidence of severe cases. The combination of monoclonal antibodies and antiviral drugs is helpful to the COVID-19 treatment of patients with HM. On the other hand, COVID-19 infection can lead to a delay of hematopoietic recovery and low immunity in patients with HM. For HM patients with COVID-19 infection, to reduce the intensity and shorten the course of radiotherapy and chemotherapy is needed. This article will review the interaction between COVID-19 infection and HM.
题目: 新冠病毒感染与恶性血液病之间的相互影响.
摘要: .新冠肺炎大流行影响了人们的生活方式。一方面，恶性血液病患者更易感染新冠病毒，且感染后更易发展成重症，有更高的死亡率；尽管恶性血液病患者对疫苗的反应性有所降低，但是接种了疫苗仍可降低病毒感染率，减少重症发生率；单克隆抗体和抗病毒药物的联合应用有助于恶性血液病患者的新冠治疗。另一方面，新冠病毒感染可导致恶性血液病患者造血恢复慢，免疫力低下，对于感染了新冠病毒的恶性血液病患者应尽量降低放化疗强度、缩短放化疗疗程。本文将对新冠病毒感染和恶性血液病之间相互影响的最新研究进展作一综述。.
Keywords: coronavirus disease 2019; hematological malignancies; COVID-19 vaccine; prognosis.