Higher Than Expected Residual Volumes of Intrathecal Baclofen - A Brief Report

Dev Neurorehabil. 2025 Jul 4:1-4. doi: 10.1080/17518423.2025.2526355. Online ahead of print.

Abstract

Intrathecal baclofen (ITB) pumps deliver baclofen effectively, but pump or catheter failures can have severe consequences. Early identification of dysfunction is crucial. In our retrospective single-site study, we evaluated whether the calculated residual baclofen volume discrepancies of -15% to -25% at routine ITB pump refills may indicate catheter dysfunction. We assessed 14 patients (11 males) undergoing 56 ITB pump refills over 12 months. One patient averaged errors of -17% over six refills and subsequently presented in acute baclofen withdrawal. Our findings suggest that volume discrepancies greater than -15% could warrant a high index of suspicion for ITB catheter or pump issues.

Keywords: Catheter; cerebral palsy; intrathecal baclofen pump; overdose; pump-malfunction.