CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments

Sci Adv. 2025 Jul 4;11(27):eadv1015. doi: 10.1126/sciadv.adv1015. Epub 2025 Jul 4.

Abstract

Microbial rhodopsins are omnipresent on Earth; however, the vast majority of them remain uncharacterized. Here, we describe a rhodopsin group found in microorganisms from cold environments, such as glaciers, denoted as CryoRhodopsins (CryoRs). A distinguishing feature of the group is the presence of a buried arginine residue close to the cytoplasmic face. Combining single-particle cryo-electron microscopy and x-ray crystallography with rhodopsin activation by light, we demonstrate that the arginine stabilizes an ultraviolet (UV)-absorbing intermediate of an extremely slow CryoRhodopsin photocycle. Together with extensive spectroscopic characterization, our investigations on CryoR1 and CryoR2 proteins reveal mechanisms of photoswitching in the identified group. Our data suggest that CryoRs are sensors for UV irradiation and are also capable of inward proton translocation modulated by UV light.

MeSH terms

  • Arginine / chemistry
  • Cold Temperature*
  • Cryoelectron Microscopy
  • Crystallography, X-Ray
  • Models, Molecular
  • Rhodopsins, Microbial* / chemistry
  • Rhodopsins, Microbial* / metabolism
  • Ultraviolet Rays

Substances

  • Rhodopsins, Microbial
  • Arginine