Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics

Yuji Huang; Boxuan Liang; Xuewei Chen; Zhiming Li; Yanhong Deng; Jiaxin Du; Yizhou Zhong; Xi Lin; Junjun Fu; Jieyu Xie; Xin Zhang; Zhenlie Huang

doi:10.1186/s12964-025-02332-7

Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics

Cell Commun Signal. 2025 Jul 4;23(1):324. doi: 10.1186/s12964-025-02332-7.

Authors

Yuji Huang^#^{1

2}, Boxuan Liang^#², Xuewei Chen^#³, Zhiming Li², Yanhong Deng², Jiaxin Du², Yizhou Zhong^{1

2}, Xi Lin², Junjun Fu³, Jieyu Xie³, Xin Zhang⁴, Zhenlie Huang^{5

6}

Affiliations

¹ Department of Cardiovascular Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
² NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, 510515, China.
³ State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
⁴ State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. zhangxinpost@139.com.
⁵ Department of Cardiovascular Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. huangzhenlie858252@smu.edu.cn.
⁶ NMPA Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, 510515, China. huangzhenlie858252@smu.edu.cn.

^# Contributed equally.

PMID: 40616101
DOI: 10.1186/s12964-025-02332-7

No abstract available

Keywords: C-X-C motif chemokine ligand 13; Human leukocyte antigen I; Lung cancer; Malignant cells; Obstructive lung disease; Tumor immune microenvironment.

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