Increased 68Ga-FAPI-04 Uptake in Cerebral Infarction

Liangxian Liu; Lin Chen; Aisheng Dong; Guorong Jia; Mingyuan Liu

doi:10.1097/RLU.0000000000006046

Increased 68Ga-FAPI-04 Uptake in Cerebral Infarction

Clin Nucl Med. 2025 Jul 7. doi: 10.1097/RLU.0000000000006046. Online ahead of print.

Authors

Liangxian Liu¹, Lin Chen¹, Aisheng Dong², Guorong Jia², Mingyuan Liu¹

Affiliations

¹ Department of Neurology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University.
² Department of Nuclear Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.

PMID: 40623130
DOI: 10.1097/RLU.0000000000006046

Abstract

FAPI PET/CT is a promising imaging tool for the assessment of brain tumors due to very low FAPI uptake of normal brain parenchyma and a high target-to-background ratio. However, FAPI uptake has been observed in nonmalignant brain diseases. We describe 68Ga-FAPI-04 PET/CT findings in a patient with chronic hemorrhagic occipital infarction. The infarcted area showed inhomogeneous 68Ga-FAPI-04 uptake mimicking malignancy. This case indicates that brain infarction should be included in the differential diagnosis of FAPI-avid brain lesions.

Keywords: FAPI; PET/CT; cerebral infarction.