Objective: To investigate the clinicopathological characteristics of patients with pyloric gland adenoma (PGA), as well as their prognosis.
Methods: Data of 30 cases from 24 patients, who had been histologically diagnosed as PGA, was retrospectively analyzed. Clinical characteristics, histopathological features, treatment and prognosis were assessed and analyzed.
Results: Among the 24 patients, there were 15 females and 9 males, with an average age of 59 years old. Ten cases were located in the stomach, 4 in the duodenal bulb and 16 in the gallbladder. The average maximum diameter was 13.5 mm and morphologically the vast majority were type 0-I. The assessment of the background mucosa identified autoimmune gastritis (AIG), Helicobacter Pylori-associated gastritis and familial adenomatous polyposis (FAP) in the stomach, ectopic gastric mucosa in the duodenum and chronic cholecystitis in the gallbladder. Endoscopic resection was performed on the vast majority of gastric and duodenal cases, while all gallbladder PGAs underwent cholecystectomy. Histologically, 33.3% of PGAs showed high-grade dysplasia.
Conclusions: Due to malignant potential, it is recommended that PGAs should be completely resected, especially if they are large or show high-grade features. For gastric and duodenal PGAs, endoscopic resection has been proven to be safe and effective. Whether PGAs occurring in the gallbladder and stomach are different tumors still requires more cases for further study.
Keywords: Clinicopathological features; Endoscopic resection; High-grade dysplasia; Pyloric gland adenoma.
© 2025. The Author(s).