A 25-Year-Old With Palpitations, Fatigue, and Migraines

Robert Benson Jones Jr; Maria L Bonanni; Debbie L Cohen

doi:10.1001/jama.2025.8861

A 25-Year-Old With Palpitations, Fatigue, and Migraines

JAMA. 2025 Jul 10. doi: 10.1001/jama.2025.8861. Online ahead of print.

Authors

Robert Benson Jones Jr¹, Maria L Bonanni^{2

3}, Debbie L Cohen²

Affiliations

¹ Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
² Division of Medical Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
³ Division of Renal Electrolyte and Hypertension, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

PMID: 40638101
DOI: 10.1001/jama.2025.8861

No abstract available

Plain language summary

A woman had palpitations, fatigue, and worsening migraines. Plasma normetanephrine concentration was elevated, plasma metanephrine concentration was within reference range, and abdominal magnetic resonance imaging showed a left infrarenal para-aortic mass. What is the diagnosis and what would you do next?