Massive Pericardial Effusion as the Initial and Main Manifestation of Fluid Overload-Associated Large B-Cell Lymphoma

Shuang Sun; Tong Li; Yang Liu; Manyan Wu; Qinghao Zhao; Nan Kang; Jiangtian Chen; Hong Chen; Junxian Song

doi:10.1016/j.jaccas.2025.104009

Massive Pericardial Effusion as the Initial and Main Manifestation of Fluid Overload-Associated Large B-Cell Lymphoma

JACC Case Rep. 2025 Jul 9;30(18):104009. doi: 10.1016/j.jaccas.2025.104009.

Authors

Shuang Sun¹, Tong Li², Yang Liu³, Manyan Wu¹, Qinghao Zhao¹, Nan Kang⁴, Jiangtian Chen¹, Hong Chen¹, Junxian Song⁵

Affiliations

¹ Department of Cardiology, Peking University People's Hospital, Beijing, China.
² Department of General Practice, Second Hospital of Hebei Medical University, Shijiazhuang, China.
³ Department of Hematology, Peking University People's Hospital, Beijing, China.
⁴ Department of Pathology, Peking University People's Hospital, Beijing, China.
⁵ Department of Cardiology, Peking University People's Hospital, Beijing, China. Electronic address: songjx@pku.edu.cn.

PMID: 40645724
DOI: 10.1016/j.jaccas.2025.104009

Abstract

Fluid overload-associated large B-cell lymphoma (FO-LBCL) is a rare and novel subtype of large B-cell lymphoma, typically characterized by effusions in the body cavity. We report, for the first time, the clinical features and treatment strategies of 3 patients with FO-LBCL who presented with massive pericardial effusion as the first and primary manifestation.

Keywords: cardiac tamponade; fluid overload-associated large B-cell lymphoma; pericardial effusion; treatment.

Publication types

Case Reports