Recent transmission analysis of Mycobacterium tuberculosis isolated from rapidly growing population region in Hangzhou china using 15-Locus MIRU-VNTR

Yinyan Huang; Qinglin Cheng; Yifei Wu; Qingjun Jia; Xuexin Bai

doi:10.1016/j.diagmicrobio.2025.116966

Recent transmission analysis of Mycobacterium tuberculosis isolated from rapidly growing population region in Hangzhou china using 15-Locus MIRU-VNTR

Diagn Microbiol Infect Dis. 2025 Jul 6;113(3):116966. doi: 10.1016/j.diagmicrobio.2025.116966. Online ahead of print.

Authors

Yinyan Huang¹, Qinglin Cheng², Yifei Wu², Qingjun Jia², Xuexin Bai²

Affiliations

¹ Department of TB Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310021, Zhejiang, China. Electronic address: 463546166@qq.com.
² Department of TB Control and Prevention, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310021, Zhejiang, China.

PMID: 40651394
DOI: 10.1016/j.diagmicrobio.2025.116966

Abstract

Background: Hangzhou, Zhejiang's capital, experienced rapid population growth from 2013 to 2023, with significant increases in 2019 and 2020.Yuhang District stood out with the most rapid population growth. The proportion of immigrant tuberculosis patients in Yuhang District remained at a high level and the prevalence of tuberculosis was severe.

Objective: To explore the impact of the rapid growth of new permanent residents in the region on tuberculosis transmission and whether there is transmission between local residents and immigrants.

Methods: We selected 91 Mycobacterium tuberculosis for MIRU-VNTR genotyping isolated from Yuhang District in 2019-2020.

Results and conclusion: The Beijing genotype was the prevalent strains in circulation within this region. Nine transmission clusters were identified, with five involving both local and immigrant populations, indicating transmission between immigrant and native. The results also raised our concerns about TB control and prevention in the Nanyuan Subdistrict of Yuhang District. The minimum estimate of the proportion of TB cases related to recent transmission was 9.89 % lower than that of previous study on 66 MDR - TB. This result reiterated the heightened tendency of MDR-TB strains to cluster and suggested a greater propensity for MDR - TB transmission than that of Non - MDR pulmonary tuberculosis.

Keywords: MIRU-VNTR; Rapidly growing population; Recent transmission; TB.