Wound healing is a complex physiological process, and the continuous inflammatory response significantly contributes to the challenges associated with effective wound healing. Consequently, extensive research has focused on the development of functional wound dressings suitable for complex wound repair, aimed at facilitating rapid wound repair. In this study, we prepared a novel nanofibers material composed of polylactic acid (PLA) and Aconiti Lateralis Radix Praeparata polysaccharide (FPS) using the coaxial electrospinning technique to enhance wound healing capabilities. The nanofibers were characterized by SEM, TEM, FTIR, and TGA-DTG. Permeability and expansion rate experiments indicated that the nanofibers possessed favorable permeability and hygroscopicity, while tensile property assessments revealed their excellent tensile property and flexibility. In vitro hemolysis and cell experiments demonstrated that the nanofibers exhibited good biocompatibility and high safety. Furthermore, the wound healing efficacy of the nanofibers material was evaluated utilizing a rat full-thickness skin defect wound model, which revealed that the FPS-PLA nanofibers effectively promoted wound healing, accelerated collagen deposition, and induced RAW264.7 macrophages polarization toward the M2 phenotype and down-regulate myeloperoxidase (MPO) at the wound site. The nanofibers demonstrated remarkable capabilities in promoting wound repair and anti-inflammatory, showing great potential in the field of wound dressings.
Keywords: Aconiti Lateralis Radix Praeparata polysaccharide; Coaxial nanofibers; Immune regulation; Wound healing.
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