Splicing inhibits premature cleavage and polyadenylation

Sheng Yang; Mengzhao Li; Chengguo Yao

doi:10.1016/j.tig.2025.06.011

Splicing inhibits premature cleavage and polyadenylation

Trends Genet. 2025 Jul 11:S0168-9525(25)00162-3. doi: 10.1016/j.tig.2025.06.011. Online ahead of print.

Authors

Sheng Yang¹, Mengzhao Li¹, Chengguo Yao²

Affiliations

¹ Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China.
² Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China; Department of Histoembryology and Cell Biology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China. Electronic address: yaochguo@mail.sysu.edu.cn.

PMID: 40651851
DOI: 10.1016/j.tig.2025.06.011

Abstract

Small nuclear ribonucleoproteins (snRNPs) U1/U2/U4/U6 are critical constituents of the spliceosome. Recent studies showed that each of them exhibits a role in the inhibition of global PCPA (premature cleavage and polyadenylation), thereby supporting the hypothesis that the splicing process inhibits PCPA. In this forum article we summarize evidence to reinforce this hypothesis and envision potential mechanisms.