Sequence homology between two membrane transport ATPases, the Kdp-ATPase of Escherichia coli and the Ca2+-ATPase of sarcoplasmic reticulum

Proc Natl Acad Sci U S A. 1984 Aug;81(15):4746-50. doi: 10.1073/pnas.81.15.4746.

Abstract

We have determined the DNA sequences of the genes encoding the three structural proteins of the Kdp-ATPase, an ATP-driven potassium transport system of Escherichia coli. Regions of the predicted amino acid sequence of KdpB, the phosphorylated protein of the system, are homologous to regions of the Ca2+-ATPase of rabbit sarcoplasmic reticulum. The phosphorylated aspartate residue of the latter is within a region of homology.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphatases* / genetics
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Evolution
  • Biological Transport, Active*
  • Calcium-Transporting ATPases* / genetics
  • Cation Transport Proteins
  • Escherichia coli / enzymology
  • Rabbits
  • Sarcoplasmic Reticulum / enzymology

Substances

  • Cation Transport Proteins
  • Adenosine Triphosphatases
  • potassium transporting ATPase
  • Calcium-Transporting ATPases

Associated data

  • GENBANK/K02670