Wall-coated open tubular column coupled with nitrogen-selective detector for routine GLC determination of diazepam, meprobamate, phenylbutazone, and thioridazine in serum

J Pharm Sci. 1980 Jul;69(7):835-8. doi: 10.1002/jps.2600690724.

Abstract

The selectivity and sensitivity provided by a wall-coated open tubular column coupled with a nitrogen-selective detector allowed rapid, accurate determination of diazepam, meprobamate, phenylbutazone, and thioridazine in serum in the same chromatographic system using 100--200 microliters of sample.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Chromatography, Gas / instrumentation
  • Chromatography, Gas / methods
  • Diazepam / blood*
  • Epilepsy / blood
  • Female
  • Humans
  • Male
  • Meprobamate / blood*
  • Meprobamate / poisoning
  • Middle Aged
  • Nitrogen / blood
  • Phenylbutazone / blood*
  • Thioridazine / blood*

Substances

  • Meprobamate
  • Phenylbutazone
  • Thioridazine
  • Nitrogen
  • Diazepam