The spatial resolution performance of a time-resolved optical imaging system using temporal extrapolation

Med Phys. 1995 Feb;22(2):201-8. doi: 10.1118/1.597457.

Abstract

Optical imaging methods are being explored as a potential means of screening for breast cancer. Previous investigations of time-resolved imaging techniques have suggested that due to the lack of photons with sufficiently small pathlengths, the spatial resolution achievable through a human breast would be unlikely to be better than a centimeter. Experimental results presented here indicate, however, that higher resolution may be achieved by extrapolating the measured temporal distribution of transmitted photons. This is performed using a least-squares fit between data and an analytic model of photon transport. The spatial resolution of a time-resolved imaging system was evaluated by measuring the edge response produced by an opaque mask embedded in the center of a 51-mm-thick, very highly scattering medium. The limiting spatial resolution was improved from about 13 mm to about 5 mm.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / prevention & control
  • Female
  • Humans
  • Least-Squares Analysis
  • Mammography / standards*
  • Mass Screening / methods
  • Mathematics
  • Models, Theoretical*
  • Online Systems
  • Time Factors