Gonadotropin-releasing hormone neurons in the rhesus macaque are not immunoreactive for the estrogen receptor

Brain Res. 1995 Jul 10;685(1-2):198-200. doi: 10.1016/0006-8993(95)00352-q.

Abstract

The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive for the estrogen receptor. These results confirm in primates what has been reported in other species and leave open the question of how the effects of gonadal steroids on GnRH neurons are mediated.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Female
  • Gonadotropin-Releasing Hormone / analysis*
  • Immunohistochemistry
  • Macaca mulatta / metabolism*
  • Neurons / chemistry*
  • Ovary / physiology
  • Receptors, Estrogen / analysis*
  • Sexual Maturation
  • Species Specificity

Substances

  • Receptors, Estrogen
  • Gonadotropin-Releasing Hormone