[Onco-gene c-fos expression in light-damaged human embryo retinal pigment epithelium and protective effect of taurine and gamma-interferon]

Zhonghua Yan Ke Za Zhi. 1995 Mar;31(2):126-8.
[Article in Chinese]

Abstract

We used well-cultured human embryo retinal pigment epithelial (RPE) cells to establish a light-damaged RPE cell model. There was no onco-gene c-fos expression in RPE cells cultured under normal condition. Immediately after 30 minutes of light exposure, onco-gene c-fos expression occurred in the RPE cells. The expression reached the highest level 1.5 hours after light exposure and disappeared 4 hours later. Taurine and gamma-interferon in different concentrations could restrain onco-gene c-fos expression in light damaged RPE cells. The restraint effects were of concentration dependence.

Publication types

  • English Abstract

MeSH terms

  • Cells, Cultured
  • Gene Expression / drug effects
  • Genes, fos*
  • Humans
  • Interferon-gamma / pharmacology*
  • Light
  • Pigment Epithelium of Eye / cytology*
  • Pigment Epithelium of Eye / embryology
  • Taurine / pharmacology*

Substances

  • Taurine
  • Interferon-gamma