We used well-cultured human embryo retinal pigment epithelial (RPE) cells to establish a light-damaged RPE cell model. There was no onco-gene c-fos expression in RPE cells cultured under normal condition. Immediately after 30 minutes of light exposure, onco-gene c-fos expression occurred in the RPE cells. The expression reached the highest level 1.5 hours after light exposure and disappeared 4 hours later. Taurine and gamma-interferon in different concentrations could restrain onco-gene c-fos expression in light damaged RPE cells. The restraint effects were of concentration dependence.