A review of mycetisms reported in Mexico and a description of two interesting cases are given. Worldwide mycetisms are rarely studied. To identify the causal agents, clinical notes were analysed and field research with some of the persons involved in the poisonings were carried out. Symptoms and field data confirm a mortal hepatotoxic poisoning and a gastrointestinal mycetism produced by Amanita and Ramaria, respectively. In addition, mycetisms produced in Mexico by Boletus, Chlorophyllum, Conocybe, Hypomyces, Panaeolus, Psilocybe, Scleroderma, and Stropharia are discussed.