Early events in the experimental interstitial lung disease induced in sheep by the Visna-maedi virus

Immunol Lett. 1993 Dec;39(1):39-43. doi: 10.1016/0165-2478(93)90162-u.

Abstract

Visna-maedi virus is a lentivirus closely related to the human immunodeficiency virus type I (HIV-I). During spontaneous infection of sheep by Visna-maedi virus an interstitial lung disease is observed. It is characterized by an alveolitis, peribronchovascular lymphoid nodules, alveolar wall thickening and myomatosis. In order to decipher the pathology of this lentiviral infection we have induced this disease in colostrum-deprived newborn lambs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Bronchoalveolar Lavage Fluid / cytology
  • Bronchoalveolar Lavage Fluid / immunology
  • Cells, Cultured
  • Female
  • Fibroblasts / microbiology
  • Leukocyte Count
  • Male
  • Pneumonia, Progressive Interstitial, of Sheep / diagnostic imaging
  • Pneumonia, Progressive Interstitial, of Sheep / immunology*
  • Pneumonia, Progressive Interstitial, of Sheep / pathology
  • Radiography
  • Sheep
  • Visna-maedi virus / growth & development
  • Visna-maedi virus / immunology*