Cognitive dysfunction in early onset parkinsonism

Acta Neurol Scand. 1994 Jan;89(1):9-14.

Abstract

Cognitive functions of 24 patients with early onset parkinsonism (age of onset before 40 years) and 24 controls were investigated by a battery of neuropsychological tests. Patients were shown to be impaired in performance IQ (PIQ), conceptual ability and regulation behavior, memory, visuospatial perception, and manual dexterity. Patients were also shown to have a higher Zung Depression score. However, analysis of the testing scores appeared to indicate that only a small portion of poor performance on neuropsychological tests are depression related. The results demonstrated that patients with early onset parkinsonism, in whom the factor of aging is not as important, still show cognitive dysfunction and suggested that Parkinson's disease itself can cause cognitive impairment.

MeSH terms

  • Adult
  • Antiparkinson Agents / adverse effects
  • Antiparkinson Agents / therapeutic use
  • Cognition Disorders / diagnosis*
  • Cognition Disorders / drug therapy
  • Cognition Disorders / psychology
  • Female
  • Humans
  • Male
  • Mental Recall / drug effects
  • Neurocognitive Disorders / diagnosis*
  • Neurocognitive Disorders / drug therapy
  • Neurocognitive Disorders / psychology
  • Neuropsychological Tests / statistics & numerical data
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / psychology
  • Psychometrics
  • Psychomotor Performance / drug effects
  • Reaction Time / drug effects

Substances

  • Antiparkinson Agents