The rapid detection of unknown mutations in nucleic acids

Nat Genet. 1993 Oct;5(2):111-7. doi: 10.1038/ng1093-111.

Abstract

The task of identifying mutations in nucleic acid sequences is a vital component of research in mammalian genetics. With the advent of the polymerase chain reaction, several useful mutation detection techniques have evolved in recent years. The different methods have complementing strengths and a suitable procedure for virtually any experimental situation is now available.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • DNA
  • Genetic Techniques*
  • Humans
  • Molecular Sequence Data
  • Mutation*
  • Nucleic Acids / genetics*
  • Polymorphism, Genetic
  • Sensitivity and Specificity

Substances

  • Nucleic Acids
  • DNA