Role of cephalosporinase in carbapenem resistance of clinical isolates of Pseudomonas aeruginosa

Antimicrob Agents Chemother. 1993 Jun;37(6):1387-9. doi: 10.1128/AAC.37.6.1387.

Abstract

With numerous imipenem-resistant clinical isolates of Pseudomonas aeruginosa as well as in vitro-selected resistant mutants, we have demonstrated, by a simple method with a powerful cephalosporinase inhibitor, BRL42715, the contribution of chromosomal cephalosporinase in resistance to imipenem in this species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / metabolism
  • Carbapenems / pharmacology*
  • Cephalosporinase / metabolism
  • Cephalosporinase / physiology*
  • Drug Resistance, Microbial
  • Humans
  • Hydrolysis
  • Imipenem / pharmacology
  • Lactams*
  • Meropenem
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology*
  • Thienamycins / pharmacology
  • beta-Lactamase Inhibitors
  • beta-Lactams*

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • Lactams
  • Thienamycins
  • beta-Lactamase Inhibitors
  • beta-Lactams
  • C6-(N1-methyl-1,2,3-trazolylmethylene)penem
  • Imipenem
  • Cephalosporinase
  • Meropenem