Gamma delta T-cell development

Curr Opin Immunol. 1993 Apr;5(2):241-6. doi: 10.1016/0952-7915(93)90011-g.

Abstract

Gamma delta T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programmed rearrangement of V gamma-gene segments. It appears that the T-cell receptor repertoire, at least of the gamma delta T cells with invariant receptors, is the result of site-directed rearrangement and cellular selection does not play a major role.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor*
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor*
  • Mice
  • Mice, Mutant Strains / genetics
  • Mice, Mutant Strains / immunology
  • Models, Biological
  • Receptors, Antigen, T-Cell, gamma-delta / genetics*
  • Receptors, Antigen, T-Cell, gamma-delta / immunology
  • Signal Transduction
  • T-Lymphocyte Subsets / cytology
  • T-Lymphocyte Subsets / immunology*
  • Thymus Gland / cytology

Substances

  • Receptors, Antigen, T-Cell, gamma-delta