Enhanced urinary excretion of leukotriene E4 in patients with mevalonate kinase deficiency

J Pediatr. 1993 Jul;123(1):96-8. doi: 10.1016/s0022-3476(05)81548-3.

Abstract

In patients with mevalonate kinase deficiency, urinary excretion of the leukotriene LTE4 was found to be elevated. A positive linear relationship between increased urinary excretion of mevalonate and LTE4 (n = 5) suggests that increased cysteinyl leukotriene synthesis is involved in the pathomechanisms of this disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Leukotriene E4
  • Male
  • Mevalonic Acid / urine
  • Phosphotransferases (Alcohol Group Acceptor)*
  • Phosphotransferases / deficiency*
  • SRS-A / analogs & derivatives*
  • SRS-A / urine
  • Urine / cytology

Substances

  • SRS-A
  • Leukotriene E4
  • Phosphotransferases
  • Phosphotransferases (Alcohol Group Acceptor)
  • mevalonate kinase
  • Mevalonic Acid