Low-dose apomorphine challenge in tardive akathisia

Neurology. 1993 Mar;43(3 Pt 1):544-7. doi: 10.1212/wnl.43.3_part_1.544.

Abstract

We challenged seven tardive akathisia patients with low-dose apomorphine (0.01 mg/kg) SC and placebo in a double-blind, random design. Apomorphine caused a significantly greater reduction in the objective (movement) but not the subjective (distress) component of akathisia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Akathisia, Drug-Induced / drug therapy*
  • Apomorphine / administration & dosage*
  • Dopamine / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Placebos

Substances

  • Placebos
  • Apomorphine
  • Dopamine