Abstract
In the present study, NADPH-diaphorase histochemistry was used to assess the temporal evolution of the number of nitric oxide (NO)-synthase containing neurones after reversible focal cerebral ischaemia in rats. The number of NADPH-diaphorase containing neurones was reduced by 50% and 90% respectively 6 and 24 h after ischaemia. L-NAME, a NO-synthase inhibitor, prevented the loss of NADPH-diaphorase containing neurones observed 6 h after ischemia but not 24 h after ischaemia, suggesting that in the early phase, nitric oxide is involved in this phenomenon.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Arginine / analogs & derivatives*
-
Arginine / pharmacology
-
Cerebral Cortex / drug effects
-
Cerebral Cortex / enzymology
-
Cerebral Cortex / pathology
-
Enzyme Inhibitors / pharmacology*
-
Ischemic Attack, Transient / enzymology*
-
Ischemic Attack, Transient / pathology
-
Male
-
NADPH Dehydrogenase / metabolism*
-
NG-Nitroarginine Methyl Ester
-
Neostriatum / drug effects
-
Neostriatum / enzymology
-
Neostriatum / pathology
-
Neurons / drug effects
-
Neurons / enzymology*
-
Nitric Oxide Synthase / antagonists & inhibitors*
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Enzyme Inhibitors
-
Arginine
-
Nitric Oxide Synthase
-
NADPH Dehydrogenase
-
NG-Nitroarginine Methyl Ester