Lack of correlation between the molecular size and the efficacy of lanthanides for potentiating GABAA currents in rat septal cholinergic neurons in culture

Brain Res. 1996 Jun 3;723(1-2):235-7. doi: 10.1016/0006-8993(96)00260-0.

Abstract

Actions of lanthanides were examined on GABAA receptor-activated responses in rat septal neurons in culture by using the whole-cell voltage-clamp technique. GABA (10 microM) currents were enhanced by these ions at 100 microM with an efficacy sequence of Pr3+ (1.11) > or = Lu3+ (1.07) > or = Gd3+ (1.02) > or = Er3+ (1.01) > or = La3+ (1: 40% increase) > or = Ce3+ (0.980) > or = Nd3+ (0.932) > or = Yb3+ (0.913) > or = Tb3+ (0.912), indicating the lack of correlation between the potentiating efficacy and ionic size of lanthanides.

MeSH terms

  • Animals
  • Cells, Cultured / drug effects
  • Cholinergic Fibers / drug effects*
  • Metals, Rare Earth / pharmacology*
  • Molecular Weight
  • Patch-Clamp Techniques
  • Rats
  • Receptors, GABA-A / drug effects*
  • Septal Nuclei / drug effects*

Substances

  • Metals, Rare Earth
  • Receptors, GABA-A