Functional significance of alterations in cardiac contractile protein isoforms

Clin Cardiol. 1996 Jan;19(1):9-18. doi: 10.1002/clc.4960190105.

Abstract

Multiple closely related, yet distinct, isoforms exist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Contractile Proteins / physiology*
  • Contractile Proteins / ultrastructure
  • Humans
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / physiology
  • Myocardial Contraction / physiology
  • Myocardium / metabolism*
  • Rabbits

Substances

  • Contractile Proteins