A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1)

Cytogenet Cell Genet. 1996;72(2-3):215-6. doi: 10.1159/000134193.

Abstract

We describe a new highly polymorphic DNA marker flanking the human ryanodine receptor gene (RYR1) at chromosome band 19q13.1. The marker is composed of a 25bp minisatellite sequence, a compound microsatellite (AC)(AT), and an oligo-T stretch. STS mapping of previously published markers from 19q13.1 helped to integrate the genetic and physical maps of this region. Together with D19S422, the new polymorphism forms a pair of markers closely flanking either side of the RYR1 gene which may be useful for linkage studies in families susceptible to malignant hyperthermia and central core disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Calcium Channels / genetics*
  • DNA, Satellite / genetics*
  • Humans
  • Molecular Sequence Data
  • Muscle Proteins / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Ryanodine Receptor Calcium Release Channel

Substances

  • Calcium Channels
  • DNA, Satellite
  • Muscle Proteins
  • Ryanodine Receptor Calcium Release Channel

Associated data

  • GENBANK/U29087