Objective: To collect extensively abnormal cytogenetic results in pregnancies obtained after intracytoplasmic sperm injection (ICSI).
Design: Case report.
Setting: University Hospital of Nantes, France.
Patient(s): A couple with 5 years of primary infertility and severe male factor undergoing ICSI procedure.
Intervention(s): Ultrasound-guided transvaginal follicular aspiration, amniocentesis, and medical abortion.
Main outcome measure(s): Serum levels of E2, beta-hCG, and fetal chromosomal karyotype.
Result(s): Ultrasonic observation at 12 weeks revealed an 8-mm thick cystic hygroma in the nuchal area. Because the karyotypic analysis was [46,XX,r(14)/45,XX,-14], medical abortion was performed at 14 weeks, after the patients gave their informed consent.
Conclusion(s): According to the prevalence of this unusual chromosomal abnormality in humans, such abnormal cytogenetic results have to be collected extensively to assess the feasibility of using ICSI procedure.