Model of a thalamocortical neurone with dendritic voltage-gated ion channels

Neuroreport. 1997 Mar 3;8(4):1063-6.

Abstract

To investigate the functional role of dendrites of thalamocortical neurones, we have used our one-compartmental model to construct a multi-compartmental model with dendritic regions chosen according to a representative soma-to-dendritic terminal path of an X cell of the cat dorsal lateral geniculate nucleus. The multi-compartmental model with dendritic low-threshold CA2+ and delayed rectifier K+ channels yields more accurate results than the one-compartmental model when simulating tonic firing and oscillatory activities, and provides a useful means for the study of propagation of excitation on the dendrites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Calcium Channels / physiology*
  • Cats
  • Dendrites / physiology*
  • Electric Conductivity
  • Geniculate Bodies / physiology*
  • Membrane Potentials
  • Models, Neurological*
  • Neurons / physiology*
  • Potassium Channels / physiology*
  • Thalamus / physiology*
  • Time Factors

Substances

  • Calcium Channels
  • Potassium Channels