Methods for cytogenetic prenatal diagnosis available in México require from women to accept the risk of procedures and to take a decision in the case of an abnormal result. We applied a questionnaire to 264 pregnant women from August 1990 to July 1991 with the purpose of describing the characteristics of these women and the factors involved in making the decision. Two hundred and nine patients (79%) accepted the procedures. The acceptance was related with a high level of studies and inversely related to their religious beliefs. The interviewer did not influence the decision; but it was important to have previous information about the procedures. Those women with the highest social, financial, and study level and those who did not practice their religion accepted the possibility of an abortion.