Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase

J Med Chem. 1997 Jun 6;40(12):1763-7. doi: 10.1021/jm9701177.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Naphthylamine / analogs & derivatives
  • 2-Naphthylamine / chemical synthesis
  • 2-Naphthylamine / chemistry
  • 2-Naphthylamine / pharmacology
  • Alkyl and Aryl Transferases*
  • Amino Acid Sequence
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacology
  • Cell Division / drug effects
  • Cell Line, Transformed
  • Cysteine / chemistry
  • Dipeptides / chemical synthesis
  • Dipeptides / chemistry
  • Dipeptides / pharmacology
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Farnesyltranstransferase
  • Genes, ras
  • Methionine / chemistry
  • Models, Molecular
  • Molecular Structure
  • Naphthalenes / chemistry*
  • Protein Conformation
  • Structure-Activity Relationship
  • Transferases / antagonists & inhibitors*
  • Tumor Cells, Cultured
  • ras Proteins / metabolism

Substances

  • Antineoplastic Agents
  • Dipeptides
  • Enzyme Inhibitors
  • Naphthalenes
  • RPR 114334
  • naphthalene
  • Methionine
  • 2-Naphthylamine
  • Transferases
  • Alkyl and Aryl Transferases
  • Farnesyltranstransferase
  • ras Proteins
  • Cysteine