Microtubule dynamics: treadmilling comes around again

Curr Biol. 1997 Jun 1;7(6):R369-72. doi: 10.1016/s0960-9822(06)00177-1.

Abstract

Although it is generally believed that microtubules have minus ends bound to the centrosome and free plus ends that exhibit dynamic instability, recent observations show that the minus ends can be free and that modulation of dynamic instability at both ends can result in treadmilling and flux in interphase cells.

Publication types

  • Review

MeSH terms

  • Interphase / physiology*
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / physiology*
  • Models, Biological
  • Movement / physiology

Substances

  • Microtubule-Associated Proteins