Variability among breath-holds frequently produces registration errors, a situation that may contribute to reproducibility error in anatomic indices. A navigator-echo-based method for real-time prospective correction of imaging slice level was applied to breath-hold cine cardiac imaging of 13 subjects. Repeat acquisitions with correction in the cardiac short-axis orientation showed significantly improved reproducibility in fractional area change and endocardial centroid location as compared with conventional noncorrected methods.