Phospholamban: a protein coming of age

Biochem Biophys Res Commun. 1997 Oct 9;239(1):1-5. doi: 10.1006/bbrc.1997.7340.

Abstract

Phospholamban is a major regulator of the kinetics of cardiac contractility, through its ability to regulate the function of the cardiac SR Ca(2+)-pump and thus the SR Ca2+ load. In vitro expression studies have provided significant information on the structure/function of the phospholamban/Ca(2+)-pump interaction. Furthermore, the generation of genetic animal models with altered phospholamban expression levels have permitted a through understanding of the physiological role of this regulatory phosphoprotein. Future studies aimed towards crystallization of phospholamban and the SR Ca(2+)-ATPase in their native SR environment may provide clues to their tertiary and quaternary structures and may further elucidate the mechanisms underlying the phospholamban regulatory effects in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / physiology*
  • Calcium-Transporting ATPases / physiology*
  • Cloning, Molecular
  • Humans
  • Models, Molecular
  • Myocardial Contraction / physiology
  • Myocardium / enzymology
  • Sarcoplasmic Reticulum / enzymology

Substances

  • Calcium-Binding Proteins
  • phospholamban
  • Calcium-Transporting ATPases