Repetition priming with nonverbal stimuli in patients with dementia of the Alzheimer type

Neuropsychology. 1998 Jan;12(1):43-51. doi: 10.1037//0894-4105.12.1.43.

Abstract

Perceptual repetition priming was examined in patients with dementia of the Alzheimer type (DAT) and normal control (NC) participants using a task involving the discrimination of geometric designs that had either a continuous ("closed") or discontinuous ("open") perimeter. With the open stimuli, the groups displayed significant and equivalent levels of priming after immediate repetition of the stimuli, whereas only the NC group primed significantly over a delay of three intervening items. Neither group demonstrated significant priming with the closed stimuli. Results indicate that under some conditions DAT patients can exhibit normal repetition priming with stimuli that do not have preexisting representations but that (due possibly to a deficiency in the level of steady-state cortical activation) this priming dissipates more rapidly in DAT patients than in NC participants.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / psychology*
  • Cognition / physiology*
  • Cues
  • Discrimination, Psychological / physiology
  • Female
  • Form Perception / physiology
  • Humans
  • Male
  • Psychomotor Performance
  • Reaction Time / physiology