Dendritic alterations in cortical pyramidal cells in the sparse fur mouse

Brain Res. 1998 Jun 22;797(1):167-72. doi: 10.1016/s0006-8993(98)00392-8.

Abstract

Ornithine carbamoyltransferase deficiency, an X-linked trait, leads to toxic hyperammonemia in sparse fur (spf/Y) mice. Quantitative analysis of the basilar dendritic tree of layer V pyramidal cells in frontoparietal cortex stained by the Golgi Kopsch method revealed a significant decrease in both the complexity of the dendritic arbor and in dendritic terminal spine density (60%) in spf/Y mice compared with controls. Such reductions may contribute to behavioral dysfunction observed in spf/Y mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Size
  • Cerebral Cortex / enzymology
  • Cerebral Cortex / pathology*
  • Dendrites / pathology*
  • Male
  • Mice
  • Mice, Mutant Strains
  • Ornithine Carbamoyltransferase / genetics*
  • Pyramidal Cells / enzymology
  • Pyramidal Cells / pathology*
  • Pyramidal Cells / ultrastructure

Substances

  • Ornithine Carbamoyltransferase