[The estimation of the level of mutations at the glycophorin A locus in subjects exposed to the chronic action of ionizing radiation]

Radiats Biol Radioecol. 1998 May-Jun;38(3):443-50.
[Article in Russian]

Abstract

11 persons, who had been irradiated chronically at low dose rate under occupational conditions in 1950s in doses 220-581 cGy according data of individual film dosimeters, and 5 control persons were examined regarding the level of glycophorin A (GPA) mutation type NO and NN in blood erythrocytes. Significantly higher level of GPA mutations type NO was registered in average in the group of exposed persons (23.2 +/- 4.6 x 10(-6)) compared with the control group (10.2 +/- 2.1 x 10(-6)) through the dose dependence was expressed slightly. The coefficient of the linear regression has equaled (2.3 +/- 1.2 x 10(-6)) Gy. The outlook on GPA assay usage in retrospective biodosimetry is discussed.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Chronic Disease
  • Dose-Response Relationship, Radiation
  • Female
  • Flow Cytometry
  • Glycophorins / genetics*
  • Glycophorins / radiation effects*
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Occupational Diseases / blood
  • Occupational Diseases / genetics*
  • Radiation Injuries / blood
  • Radiation Injuries / genetics*
  • Regression Analysis
  • Retrospective Studies
  • Time Factors

Substances

  • Glycophorins