Local administration of L-703,081 using a composite polymeric stent reduces platelet deposition in canine coronary arteries

Am J Cardiol. 1998 Sep 1;82(5):673-5, A8. doi: 10.1016/s0002-9149(98)00418-4.

Abstract

We compared the effect on platelet deposition of the glycoprotein IIb/IIIa receptor antagonist L-703,081, administered locally via a drug delivery stent, with that of a standard metal stent in a canine coronary model. There was a significant reduction in platelet deposition using the L-703,081-impregnated stent compared with the bare metal stent. This study demonstrates an alternative route of delivery of GPIIb/IIIa antagonists with potential advantages over systemic administration.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biological Availability
  • Coronary Circulation / drug effects*
  • Coronary Vessels / drug effects*
  • Dogs
  • Drug Implants
  • Equipment Design
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / pharmacokinetics
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
  • Polyesters*
  • Stents*
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Drug Implants
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Polyesters
  • polycaprolactone