Abstract
Several proteins have been identified as candidate cell-surface receptors for the complement protein C1q. Some of these also interact with the structurally-related collectin proteins. Previous descriptions of C1q-binding properties of cells, and information on the cellular distribution of candidate receptors suggest that there is more than one physiologically relevant receptor for C1q. Two such candidate receptors, cell-surface calreticulin (also referred to as cC1qR or collectin receptor) and megalin are discussed in this review.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Calcium-Binding Proteins / isolation & purification
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Calcium-Binding Proteins / metabolism*
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Calreticulin
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Carrier Proteins / isolation & purification
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Carrier Proteins / metabolism*
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Cattle
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Collectins
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Complement C1q / metabolism*
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Dimerization
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Endocytosis
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Heymann Nephritis Antigenic Complex
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Humans
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Hyaluronan Receptors*
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Membrane Glycoproteins / metabolism*
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Mitochondrial Proteins
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Molecular Sequence Data
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Receptors, Complement / isolation & purification
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Receptors, Complement / metabolism*
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Ribonucleoproteins / isolation & purification
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Ribonucleoproteins / metabolism*
Substances
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C1QBP protein, human
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Calcium-Binding Proteins
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Calreticulin
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Carrier Proteins
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Collectins
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Heymann Nephritis Antigenic Complex
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Hyaluronan Receptors
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Membrane Glycoproteins
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Mitochondrial Proteins
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Receptors, Complement
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Ribonucleoproteins
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complement 1q receptor
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Complement C1q