Abstract
F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn
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Antibodies / pharmacology
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Axons / physiology*
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Axotomy
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Blotting, Northern
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Cells, Cultured
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Extracellular Matrix / metabolism
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Gene Expression Regulation
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Growth Substances*
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In Situ Hybridization
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Intercellular Signaling Peptides and Proteins
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Nerve Regeneration*
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Neural Cell Adhesion Molecules / immunology
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Neural Cell Adhesion Molecules / metabolism*
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Neurites / drug effects
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Neurites / physiology
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Neurons, Afferent / physiology*
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Peptides*
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Peripheral Nerve Injuries*
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Peripheral Nerves / embryology
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Peripheral Nerves / metabolism*
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RNA, Messenger / analysis
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Rats
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Rats, Sprague-Dawley
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Schwann Cells
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Sciatic Nerve
Substances
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Antibodies
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Neural Cell Adhesion Molecules
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Peptides
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RNA, Messenger
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Spon1 protein, rat